Comprehensive modifications: LNA, cEt, 2’-MOE, 2’-OMe, PS, Fluorophores modifications.
Flexible: Synthesis scale from micrograms to kilograms, flexible packaging options, and precise quantification.
High quality: Customizable QC standards, ISO 13485:2016, from RUO to GMP compliance, HPLC purity up to 90%.
| Service | Product Type | Modifications | Length(nt) | Purification | QC | Deliverable |
| gapmer-ASO | 2-OMe-ASO | First and last 5 bases with 2‘-OMe, all PS | 16~20 | HPLC | MSoptional: HPLC, SEC-HPLC | Tube or customized lyophilized RNA COA report (electronic) |
| 2-MOE-ASO | First and last 5 bases with MOE, all PS | |||||
| LNA-ASO | First and last 3 bases with LNA, all PS | |||||
| cEt-ASO | First and last 3 bases with cEt, all PS | |||||
| PS-ASO | First and last 5 linkages with PS | |||||
| mixer-ASO | 2-OMe-ASO | All bases with 2'-OMe and PS | ||||
| MOE-ASO | All bases with MOE and PS | |||||
| LNA-ASO | All bases with LNA and PS | |||||
| cEt-ASO | All bases with cEt and PS | |||||
| PS-ASO | All linkages with PS |
Download the order form "Tsingke_RNA_Order Form.1.1.1.250815.csv" below and email it to info@tsingke.com.cn, or "Send Your Request" to submit your inquiry online. Please refer to "Tsingke_RNA_Modification List_1.1.1.250815.csv" sheet to paste special base and internal modification codes in your sequence.
The most commonly used modification in antisense oligonucleotides is the phosphorothioate (PS) backbone, which enhances resistance to nuclease degradation.
A full PS backbone is often applied to improve stability, extend circulation time, and enhance cellular uptake, particularly in the absence of delivery agents. However, PS modification may slightly reduce melting temperature (Tm) and increase non-specific protein binding, which in some cases can contribute to immune-related effects.
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