Last updated: 2026/06/01
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- Self-Assembled Nanoparticle Vaccines Elicit Robust Protective Immune Responses against Type O Foot-and-Mouth Disease Virus Infection
- De novo design of hypercompact transcript degraders by engineering substrate-specific toxins and Cas6-CBS system
- Mechanism for the substrate recognition by a eukaryotic DNA N6-adenine methyltransferase complex
- Single molecule spectrum dynamics imaging with 3D target-locking tracking
- Treg-microglia partnership in the injured spinal cord preserves Treg cell function and regulates microglial cholesterol metabolism
- A self-cascade nanoCRISPR prompts transcellular penetration to potentiate gene editing and tumor killing
- Engineered Fusion Enzyme-Mediated Non-Consecutive Cyclization-Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin
- Distinct Phage-Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes
- Tumor cells promote immunosuppression in ovarian cancer via a positive feedback loop with MDSCs through the SAA1–IL-1β axis
- Bioinspired Nanoparticles Prevent blue-light-induced Skin Hyperpigmentation via FZD2-TYR-melanin pathway
- Auranofin facilitates gemcitabine sensitivity by regulating TXNRD1-related ferroptosis in pancreatic ductal adenocarcinoma
- TGF-βI/FERMT2/COL6A1 Reciprocal Loop Drives Tumor-Stroma Crosstalk and Promotes Peritoneal Metastasis in Gastric Cancer
- YY1-induced USP43 drives ferroptosis suppression by FASN stabilization and subsequent activation of SLC7A11 in ovarian cancer
- Hypoxia-induced m6A demethylation promotes hepatocellular carcinoma progression by preventing the degradation of Gal-1 mRNA
- IRP1/ARID3A complex promotes pancreatic cancer chemoresistance by suppressing CYGB-related ferroptosis
- 8-Chloroadenosine suppresses hepatocellular carcinoma progression via ADAR1/PPARγ axis-mediated lipid metabolism
- PFKM promotes chemoresistance in lung adenocarcinoma by regulating RAB8B mediated exosome release
- Eco-engineered recombinant collagen III-PEG hydrogels with curcumin synergy for accelerated skin regeneration: A green crosslinking strategy in wound therapeutics
- Bovine viral diarrhea virus E2 targets SLC3A2 to modulate lipid peroxidation for replication advantage
- CircNCX1 contributes to mitochondrial fusion in cardiomyocyte by mediating the expression of mitofusin 2
- Akkermansia muciniphila-derived outer membrane protein Amuc_1100 promotes acetylation of RING Finger Protein 181 promoter and mediates Autophagy Related 7 ubiquitination to activate CD8+ T cells in lung adenocarcinoma
- Ginsenoside compound K ameliorates depressive-like behaviors by targeting kynurenine 3-monooxygenase
- LEF1 confers resistance to DNA-damaging chemotherapies through upregulation of PARP1 and NUMA1 in ovarian cancer
- H3K9 acetylation-dependent CHAC1 transcription in dihydroartemisinin-induced hepatic stellate cell ferroptosis
- Sensitive red fluorescent indicators for real-time visualization of potassium ion dynamics in vivo
- Bile acid synthesis dysregulation in liver diseases promotes ectopic expansion of oral streptococci in the intestine
- A designed hybrid pathway for efficient synthesis of D-pantothenate in E. coli
- Development of a thermophilic l-arabinose-inducible system in Acetivibrio thermocellus (Clostridium thermocellum)
- Expanding the Chemistry of Acyl Diazo Electrophile as a Tunable Warhead for Covalent Targeting of KRAS (G12D) Mutant
- Insulin signalling-associated cell fate promotes neoplastic invasiveness in non-functioning pituitary gonadotroph adenoma via cis-regulatory elements activation
- The Mechanism of Ferroptosis Regulating Granulosa Cell Apoptosis and Oxidative Stress Through the NF-κB/PTGS2 Axis in Porcine Atretic Follicles
- Effect of Nano-Selenium on Intestinal Oxidative Stress Induced by H2O2 in Mice
- Efficient site-specific recombination by self-activating split-Dre recombinase in mammalian cells and E. coli
- HIF1A regulates follicular atresia through O-GlcNAcylation-mediated VEZF1/ET-1/FOXO1/BAX signaling in porcine granulosa cells
- PomiR164 targets PoLBD25 to promote early flowering in tree peony
- Ectomycorrhizal-mediated lignin pathway activation enhances phosphorus use efficiency in Pinus massoniana
- Mutations in the GSTe2 Promoter in the Emamectin Benzoate-Resistant Strain of Spodoptera frugiperda Contribute to Elevated Expression Levels and Enhanced Metabolic Detoxification Capacity against Emamectin Benzoate
- HMGCS2 attenuates mitochondrial dysregulation and renal fibrosis induced by triclosan
- Prognostic associations of PFAS in ovarian cancer: Insights from exploratory analysis
- m6A-binding protein YTHDF2 alleviates 3-nitropropionic acid–induced mitochondrial dysfunction of goat granulosa cells
- PCR-CRISPR/Cas12a-based fluorescence and lateral flow dipstick platforms for efficient screening of CD71 biallelic mutants
- Electroactive PVTF films functionalized with collagen enhance osteogenic differentiation and bone regeneration
- Comparative transcriptomic analysis of biofilm formation mechanism in Lacticaseibacillus paracasei SB27
- Multi-omics dissection of fatty acid metabolism heterogeneity identifies PRDX1 as a prognostic marker in bladder cancer
- Calycosin attenuates mitochondrial damage and pyroptosis in heart failure via the Nrf2/ROS/TXNIP pathway
- A Rapid Hairy Root Transformation System for Characterizing Haloacid Dehalogenase in Aluminum Toxicity Resistance in Stylosanthes
- Nanomedicine-mediated co-expression of PD-1 blockade and CXCL9 synergizes T cell infiltration and activation in solid tumor
- Soluble Sema4D From γδ T Cells Exerts Osteoblast Inhibition via Plexin-B/mTOR Signalling Contributing to Pathogenesis of Bisphosphonate-Related Osteonecrosis of the Jaws
- Mycobacterial tyrosine phosphatase PtpB affects host cytokine expression by dephosphorylating ERK1/2 and STAT3
- Erianin Reverses 5-FU Resistance by Targeting CALM1/CAMKK2 and Activating Autophagy in Colorectal Cancer
- Pi Ji Pills reshape the pancreatic cancer immune microenvironment and enhance the efficacy of gemcitabine through dual mechanisms of PI3K/AKT pathway blockade and NETs inhibition
- Anti-tumor effect of flavonoids isolated from Bidens Pilosa L. by regulating the activity of myeloid-derived suppressor cells within the tumor microenvironment in mice
- Dopamine receptor D1-mediated suppression of liver fibrosis via Hippo/Yes-associated protein 1 signaling in levodopa treatment
- Novel BCR-Targeting Fusion Proteins for Antigen-Specific Depletion of Alloreactive B Cells in Antibody-Mediated Rejection
- Electrochemical detection of fluoride based on its inhibition on pyrophosphatase activity
- Isoleucyl-tRNA synthetase depletion reveals vulnerabilities in Mycobacterium abscessus and Mycobacterium marinum
- Huangqi Baihe Granules Attenuate Hypobaric Hypoxia-Induced Brain Injury via HIF-1a/p53/Caspase-3 Pathway
- Vitamin D3 promotes white fat beige through IL-27/P38MAPK/PGC-1α pathway
- Myristic Acid Remodels Sphingolipid Metabolism via Dual Pathways: Canonical d18-Sphingolipid Regulation and Non-Canonical d16-Sphingolipid Synthesis
- Proteomic Screening for Cellular Targets of the Duck Enteritis Virus Protein VP26 Reveals That the Host Actin–Myosin II Network Regulates the Proliferation of the Virus
- Synergistic Effects of Rotenone and Abamectin on Physiological Suppression, Population Inhibition, and Ion Disruption of Bursaphelenchus xylophilus
- Antimicrobial and Nutritional Potentials of Bacillus Strains
- Co-expression network analysis identifies AtrANS, a gene essential for anthocyanin pigmentation in Akebia trifoliata pericarp
- Comprehensive safety assessment of Qiwei Tiexie Pill: integrating histopathological, biochemical, and metabolomic analyses in a rat model
- Targeted ferroptosis of myofibroblasts by tubeimoside I attenuates hypertrophic scar formation
- Genetic diversity analysis of proso millet (Panicum miliaceum L.) germplasm resources based on phenotypic traits and SSR markers
- Coprinellus disseminates ArsM confers multi-layer arsenic resistance in transgenic tobacco by coordinating detoxification, photosynthetic protection, and stress signaling
- Bruceine A derivative P1 alleviates renal inflammation via Tnfrsf12a pathway in diabetic nephropathy
- Senkyunolide I alleviates allergic rhinitis by inhibiting JAK1/3-STAT3/6 and JNK signalings
- Tumor-associated neutrophils promote breast cancer progression via RLN2/RXFP1-C6orf99-STAT3 axis
- Lactuca indica L. polysaccharide ameliorates type 1 diabetes via gut microbiota-SCFAs-IRS-1/PI3K/GLUT4-MYD88/NF-κB axis
- Selenium improves behavioral performance in a rat model of autism spectrum disorder by mitigating oxidative stress and modulating the Sirt1/Keap1/Nrf2/HO-1 signaling pathway
- Aloperine exerts anti-tumor effect and activates the tumor cell-intrinsic STING pathway in gallbladder cancer
- Therapeutic potential of luteolin in central precocious puberty: insights from a danazol-induced rat model
- The VmCarEs-6 gene in the Therioaphis trifolii (Monell) enhances pesticide sensitivity by inhibiting detoxification metabolism1
- Engineering Riboflavin-Overproducing Bacillus subtilis via Pathway Gene Overexpression
- Identification of a Novel β-1,4-Galactosyltransferase from Haemophilus parainfluenzae for Efficient Biosynthesis of Lacto-N-neotetraose in Escherichia coli
- Cholesterol metabolic reprogramming drives the onset of DLBCL and represents a promising therapeutic target
- Effects of DNMT1 and TET2 on Proliferation and Differentiation of Goose Embryonic Myoblasts
- Lnc237 regulates duck myoblasts proliferation and differentiation via the miR-22-5p/MYL9 axis
- Autophagy and exosomes play different roles in the disposal of unwanted cellular materials
- Genome-wide identification and functional prediction of long non-coding RNAs in plastic growth in Alternanthera philoxeroides
- Single-cell multiomics reveals multiple adipogenic pathways and diverse multilineage specializations during embryonic fat tail morphogenesis
- The upregulation of GDF15 is controlled epigenetically by oncogenic TCF19 signaling in human hepatocellular carcinoma
- SeXTH23 enhances salt tolerance by regulating succulence and osmotic adjustment in aspen hybrid
- mTOR-autophagy axis regulation by intermittent fasting promotes skeletal muscle growth and differentiation
- NLR Risk Score for Predicting Patient Prognosis in Hepatocellular Carcinoma and Identification of Oncogenic Role of NLRP5 in Hepatocellular Carcinoma
- The discovery of marine natural product Streptochlorin and its inhibition of Banana fusarium wilt by targeting the GPI pathway
- Dephosphorylation of astrocyte elevated gene-1 protein upregulates eIF4E expression to promote gastric cancer progression
- NITAC-Mediated ISGylation of eIF4E2 Attenuates GSK3β Proline-Directed Kinase Activity, Conferring Cytoprotection
- Effects of ACOT7 gene variants on productive performance in Qiandongnan small Xiang goats
- LncRNA HOXA11-AS promotes the cell proliferation, migration, invasion and inhibits cell apoptosis in esophageal squamous cell carcinoma
- REV1‑targeting inhibitor JH‑RE‑06 induces ferroptosis via NCOA4‑mediated ferritinophagy in colorectal cancer cells
- Identification of novel small molecules as potential SGLT2 inhibitors through combined virtual screening and experimental validation
- De Novo Biosynthesis of Scopoletin from Glucose by Engineered Saccharomyces cerevisiae
- Chenodeoxycholic acid (CDCA) alleviates high fat diet-induced lipid deposition via FXR/SHP/PIAS1/SUMO1-dependent SREBP1K264 SUMOylation in yellow catfish
- Pathogenic glycosyltransferase genes and potential therapeutic drugs in pressure overload-induced heart failure
- Genomic diversity in Chinese Holstein cattle and genome-wide association study for body conformation traits
- Morpho-phylogenetic evidence reveals new species and records of Beltraniaceae (Amphisphaeriales, Sordariomycetes) from southern China
- A bivalent SARS-CoV-2 subunit vaccine for cats neutralizes both the original ancestral strain and BA.1 Pseudovirus carrying the 453F and 501 T mutation
- CircTTC3 regulates the osteogenic differentiation of adipose-derived mesenchymal stem cells via miR-205/Smad3 axis
- KRAS mutation promotes immune escape of lung adenocarcinoma via ZNF24/SLC7A5/PD-L1 axis
- Identification of hub gene and immune infiltration in Lyme disease revealed by weighted gene co-expression network analysis and machine learning
- CRISPR/Cas9 Editing of the OsLOX3 Gene Enhances Rice Grain Weight and Seed Vigor
- Efficacy of Whole-Cell-Based Mono- and Bi-Valent Vaccines Against Nocardia seriolae and Aeromonas veronii in Largemouth Bass, Micropterus salmoides
- ORMDL2 Promotes the Growth of Glioma through mTORC1-Mediated Fatty Acid Metabolism
- Characterization and Development of Salt-Resistant Aspergillus oryzae for Marine-Derived Enzyme Expression
- Targeting FOXK2 in triple-negative breast cancer: Role of the P53/MCAS1/miR-211–5p regulatory axis
- PMAIP1 mediates endoplasmic reticulum stress in human dental pulp stem cells during pulpitis pathogenesis
- Human Umbilical cord blood cells-secreted exosomal MFG-E8 regulates microglia polarization and ameliorates hypoxic-ischemic brain damage in neonatal rats by SOCS3/STAT3 axis
- Human CXCL17 binds and activates fish GPR25 orthologs
- GenX induces offspring vascular endothelial ferroptosis by targeting GPX4 for ubiquitination-dependent degradation
- F-box only protein (FBXO) family genes in cattle (Bos taurus): Genome-wide identification and functions in the skeletal muscle development
- Nanoparticle-based biosensors coupled with loop-mediated isothermal amplification for rapid, visual, and in-field identification of pathogenic Leptospira
- Malignant epithelia cells-derived spermine induces APOE+ macrophages to suppress tumor immunity in adenocarcinoma of the esophagogastric junction
- Selection and Validation of Reference Candidate Genes for qRT-PCR Analysis in the Developing Fruit of Phyllanthus emblica L.
- Probiotic VSL#3 alleviates intrahepatic cholestasis of pregnancy by upregulating farnesoid X receptor-fibroblast growth factor 15 through regulation of the gut microbiota
- Differentiation of Human Umbilical Cord Mesenchymal Stem Cells Into Pre-Granulosa Cells and Further Maturation
- PDGFC facilitates enzalutamide resistance in prostate cancer through activation of the Rap1-MAPK pathway
- DPV UL38 stabilizes MFN2 to subvert MAVS-mediated antiviral immunity in ducks
- Electroacupuncture Regulates Mitochondria-Endoplasmic Reticulum interactions via Fn1 in a Parkinson’s Disease Model: Transcriptomic Evidence
- Dietary Glycyl-Glutamine Supplementation Improves Growth, Immunity, Antioxidant Capacity, and Apparent Digestibility of Weaned Piglets
- Effects of Dietary Threonine Levels on Growth Performance, Biochemical Parameters, Muscle Quality, and Intestinal Microflora of Rice Field Eel (Monopterus albus)
- Ethyl pyruvate shields the brain from oxidative damage: a Keap1-Nrf2-dependent mechanism in subarachnoid hemorrhage
- C/EBP-β/MeCP2/Wnt Axis Participates in the Testicular Injury in Rats Under Simulated Microgravity Conditions
- β2-Microglobulin: A potential novel prognostic indicator for neuroblastoma
- Characterization of Integrin β1 and its effects on cell adhesion, migration and apoptosis in Sebastes schlegelii
- LILRB4 in tumor-associated macrophage regulates macrophage polarization and glioblastoma progression via STAT3/IL10 axis
- Maternal-Fetal Interface Cell Dysfunction in Patients With Preeclampsia Revealed via Single-Cell RNA Sequencing
- Sex-Associated Indels and Candidate Gene Identification in Fujian Oyster (Magallana angulata)
- Improvement of RNAi efficiency by delivering of dsRNA formulated with cell-penetrating disulfide polymer in the fall Armyworm, Spodoptera frugiperda
- MAO-A inhibition alleviates sepsis-driven lung injury via Nrf2/HO-1 pathway activation and suppression of pyroptosis
- Midkine and TNFSF10 as downstream molecules of type I interferon are involved in the treatment of myelofibrosis
- Time-series transcriptome profiling of liver regeneration in ALLPS models of mice identifies the Cyp8b1 as a potential target for hepatocyte proliferation
- A rapid and ultrasensitive CRISPR/Cas12a-based assay for the accurate identification of T-even type phages
- Lethal endotoxin (ccdB) based counterselection improved the efficiency of sequential gene editing in Escherichia coli
- Phylogenetic Framework, a New Species, and Two New Species Records for China in Rhizopogon
- Response surface methodology optimization extraction of polysaccharide from Lilium brownii F.E. Brown var. viridulum Baker/Longya Baihe and its biological activities
- Hsa_circ_0122913 suppresses the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells and is involved in the effects of icariin treatment via sponging miR‑501‑5p
- WGCNA and LASSO regression-based selection and validation of microRNA biomarkers of β-thalassemia
- Synthesis of Formononetin Derivatives and Their Protective Effects Against Oxidative Stress
- Effects of ethanol exposure and withdrawal on olfactory sensitivity and learning and memory in honeybees(Apis mellifera)
- IL-1β restrains its own apoptosis-promoting activity via NF-κB (RelA) Ser276/p62-mediated elimination of damaged mitochondria in chondrocytes
- Rhein Inhibits Podocyte Ferroptosis and Epithelial-Mesenchymal Transition in Diabetic Nephropathy by Activating the SIRT1/p53/SLC7A11 Pathway
- Comparative temporal transcriptome analysis identifies genes involved in gonadal differentiation and development in Pacific abalone
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