Achieving sufficient cellular uptake and endosomal escape
Mitigating off-target effects and immune stimulation
Ensuring stability in vivo for durable effects
The synthesis process is complex and scaling up production incurs high costs.
Antisense oligonucleotides with a variety of backbone and sugar modifications (e.g., PS, MOE, LNA).
Dual-stranded RNAs with chemical modifications (e.g., 2'-F, 2'-O-Me) for improved stability and RISC loading.
A wide range of chemical modifications and conjugate options (e.g., GalNAc, cholesterol).
Comprehensive QC including HPLC, MS, and functional assays.
Extensive experience in synthesizing complex, modified oligonucleotides.
Capabilities from research-grade to GMP-level manufacturing.
Oligos are functionally validated in relevant cellular models.
Successful delivery of multiple strategic partnerships and numerous mg/g/kg-scale orders with guaranteed quality
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